Dear Dr Lee, what an incredible story! I am fully aware of so much you say about vitamin deficiency and the very unusual and virtually unknown effects of thiamin deficiency. Swelling of the salivary glands was reported very many years ago as Von Miculick's (spelling?)disease. You may be interested to know that this kind of thing is happening in the U.S. and is causing disease chaos. The interesting difference is that instead of total food deprivation, it is being caused by an excess of empty calories, thus producing a RELATIVE thiamin deficiency. That is, as you know, the secret of beriberi and I have seen beriberi at the Cleveland Clinic Foundation, unrecognized by the attending physican because we have collectively forgotten that nutritional deficiency diseases occurred here and because of "vitamin enrichment" they are supposedly conquered and only of historical interest. I have seen and reported thiamin deficient febrile lymphadenopathy in two children that I encouontered at the Cleveland Clinic and I remember a child who was admitted to the I C U with cardiomyopathy that was ignored as a case of beriberi. You may be interested to know that thiamin triphosphate has now been reported to be synthesized from TPP by the addition of inorganic phosphate. The energy for this comes from the respiratory chain. This means that ANY form of mitochondrial disruption will give rise to a deficiency of TTP.
I was intrigued by your discussion of NO because that has come up recently in a research paper. Its deficiency is as lethal as its excess. I have also known about methyl glyoxal, another metabolite that has been ignored. The body requires a balance between Yin ("not too little") and Yang ("not too much"), something that you guys have been telling us for centuries. Frankly, I have a new name for homo sapiens, homo stupidus. Please visit Evidence Based Complementary Alternative Medicine on line. Go to the archives and look up my article entitled "Dysautonomia, a heuristic approach to a revised etiology for disease". Beriberi is the prototype of dysautonomia and is the common route to disease. This is because oxidative metabolism affects the limbic system first because of its massive oxygen requirement. The control mechanisms go haywire and lead to dysautonomia. If prolonged or becoming gradually worse, it leads to organic disease in the body. I really believe that disease starts this way because of our dissolute ideas in the U.S. about the discipline of diet. Please tell me where you reside now and your present age.
Your book needs to be given to the world. You could do this by going on line to the Soil and Health Library. This is run by a Stephen Solomon as a hobby and he publishes out-of-print books and might print yours. Was it ever published?? Please keep in touch. You have a cornucopia of inromation.
Derrick Lonsdale
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